Drug Profile


Alternative Names: AVP-923; Dextromethorphan HBr/quinidine sulfate; Dextromethorphan hydrobromide/quinidine sulfate; Neurodex; Nuedexta; Quinidine/dextromethorphan; Zenvia

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Center for Neurologic Study
  • Developer Avanir Pharmaceuticals
  • Class Analgesics; Antitussives; Cinchona alkaloids; Morphinans; Quinuclidines; Small molecules
  • Mechanism of Action Cytochrome P 450 enzyme system inhibitors; NMDA receptor antagonists; Norepinephrine plasma membrane transport protein inhibitors; Serotonin plasma membrane transport protein inhibitors; Sigma-1 receptor agonists; Sodium channel antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Marketed Emotional lability
  • Phase II Agitation; Drug-induced dyskinesia; Migraine
  • No development reported Neuropathic pain
  • Discontinued Diabetic neuropathies

Most Recent Events

  • 01 Mar 2017 Avanir completes a phase II trial in Migraine in USA (NCT02176018)
  • 08 Jun 2016 Adverse events and efficacy data from the PRISM II trial released by Avanir Pharmaceuticals
  • 22 Sep 2015 Efficacy and adverse events data from a phase II trial inAgitation released by Avanir Pharmaceuticals
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