Drug Profile


Alternative Names: IDN-6556; PF-03491390; PF-3,491,390

Latest Information Update: 21 Jun 2017

Price : $50

At a glance

  • Originator Idun Pharmaceuticals
  • Developer Conatus Pharmaceuticals
  • Class Amides; Antifibrotics; Fluorobenzenes; Hepatoprotectants; Pentanoic acids; Phenyl ethers; Small molecules
  • Mechanism of Action Apoptosis inhibitors; Caspase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hepatic fibrosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hepatic fibrosis; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Portal hypertension
  • Phase I/II Type 1 diabetes mellitus
  • Suspended Alcoholic hepatitis; Liver failure
  • No development reported Liver disorders
  • Discontinued Septic shock

Most Recent Events

  • 16 Jun 2017 Pharmacodynamics data from an in vitro study in Liver disorders released by Conatus Pharmaceuticals
  • 04 May 2017 Conatus initiates enrolment in the phase IIb ENCORE-LF trial for Liver cirrhosis due to nonalcoholic steatohepatitis
  • 15 Mar 2017 Conatus Pharmaceuticals plans the phase IIb ENCORE-LF trial for decompensated non-alcoholic steatohepatitis cirrhosis, in the second quarter of 2017
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