Drug Profile


Alternative Names: Anti-PDGFRa MAb - MedImmune; MEDI-575

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Cambridge Antibody Technology
  • Developer MedImmune
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Platelet-derived growth factor alpha receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Glioblastoma; Non-small cell lung cancer; Solid tumours

Most Recent Events

  • 01 May 2013 MedImmune completes a phase II trial in Glioblastoma (recurrent disease) in USA (NCT01268566)
  • 21 Mar 2013 Discontinued - Phase-I for Solid tumours (late-stage disease) in Japan (IV)
  • 21 Mar 2013 Discontinued - Phase-I/II for Non-small cell lung cancer (combination therapy, first-line therapy, late-stage disease) in USA, Canada, Hungary and Poland (IV)
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