Cabazitaxel

Drug Profile

Cabazitaxel

Alternative Names: 116 258; Jevtana; RPR 116258; RPR 116258A; Taxoid-116258; TXD 258; XRP6258

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator sanofi-aventis
  • Developer AIO Studien gGmbH; Bristol Haematology and Oncology Centre; European Organisation for Research and Treatment of Cancer; German Breast Group; Sanofi; SCRI Development Innovations; Sidney Kimmel Cancer Center; University Hospitals Bristol NHS Foundation Trust
  • Class Antineoplastics; Taxanes
  • Mechanism of Action Tubulin inhibitors; Tubulin polymerisation promoters
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Prostate cancer
  • Phase II Brain metastases; Breast cancer; Germ cell and embryonal neoplasms; Liposarcoma; Penile cancer; Small cell lung cancer; Urogenital cancer
  • Phase I/II Solid tumours
  • Phase I Gastric cancer; Head and neck cancer

Most Recent Events

  • 17 Aug 2017 University of California and Sanofi initiates enrolment in a phase II trial for Prostate cancer (Combination therapy, Hormone refractory, Metastatic disease) in USA (NCT02844582)
  • 20 Jul 2017 Sanofi completes a phase II trial in Breast cancer (Metastatic disease, Second-line therapy or greater, Recurrent, Late-stage disease) in Greece (IV) (NCT01693549)
  • 23 Jun 2017 Sanofi completes a phase I trial in Prostate cancer (Combination therapy, Hormone refractory, Metastatic disease, First-line therapy) in USA (IV) (NCT01594918)
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