Crenolanib

Drug Profile

Crenolanib

Alternative Names: ARO-002; ARO-002-26; CP-868,596; CP-868,596-26; Crenolanib besilate; Crenolanib besylate; IND 112201

Latest Information Update: 13 Oct 2017

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At a glance

  • Originator Pfizer
  • Developer AROG Pharmaceuticals; University of Ulm
  • Class Antineoplastics; Benzimidazoles; Piperidines; Quinolines; Small molecules
  • Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; Platelet derived growth factor alpha receptor antagonists; Platelet-derived growth factor beta receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioma; Acute myeloid leukaemia; Soft tissue sarcoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia; Gastrointestinal stromal tumours
  • Phase II Glioblastoma; Non-small cell lung cancer
  • Phase I Cancer; Gastric cancer; Glioma; Oesophageal cancer
  • Preclinical Systemic mastocytosis
  • Research Soft tissue sarcoma

Most Recent Events

  • 29 Aug 2017 Arog Pharmaceuticals plans a phase III trial for Acute myeloid leukaemia (Newly diagnosed) in (NCT03258931)
  • 18 Aug 2017 Arog Pharmaceuticals plans a phase III trial for Acute myeloid leukaemia (Refractory metastatic disease; Second-line therapy; Adjunctive therapy) (NCT03250338)
  • 02 Jun 2017 interim efficacy data from a phase II trial in Acute myeloid leukaemia presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
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