Drug Profile


Alternative Names: AIDS-105293; Dapivirine gel; Dapivirine intravaginal ring; Dapivirine IVR; Dapivirine ring 004; R-147681; TMC-120

Latest Information Update: 23 Mar 2017

Price : $50

At a glance

  • Originator Tibotec BVBA
  • Developer International Partnership for Microbicides; Janssen Infectious Diseases BVBA
  • Class Antivirals; Nitriles; Pyrimidines; Small molecules
  • Mechanism of Action Non-nucleoside reverse transcriptase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III HIV infections

Most Recent Events

  • 14 Mar 2017 International Partnership for Microbicides and Gilead Sciences plan the REACH phase II trial for HIV infection (Prevention, In volunteers, Combination therapy) in South Africa (NCT03074786)
  • 13 Feb 2017 Efficacy data from the phase III ASPIRE trial in HIV infection presented at the 24th Conference on Retroviruses and Opportunistic Infections (CROI- 2017)
  • 06 Feb 2017 Suspended - Phase-I for HIV infections in USA (Rectal) (NCT03044379)
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