Research programme: pyrimidinedione analogues - ImQuest/Samjin

Drug Profile

Research programme: pyrimidinedione analogues - ImQuest/Samjin

Alternative Names: IQP-0528; IQP-0568; IQP-0589; IQP-1187; Second-generation pyrimidinediones - ImQuest/Samjin

Latest Information Update: 22 Jul 2014

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At a glance

  • Originator Samjin Pharmaceutical Company
  • Developer ImQuest Life Sciences; University of Utah
  • Class Pyrimidinones; Small molecules
  • Mechanism of Action Hepatitis C virus replication inhibitors; RNA-directed DNA polymerase inhibitors; Virus internalisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Hepatitis B; Hepatitis C; HIV infections

Most Recent Events

  • 21 Mar 2017 Johns Hopkins University ImQuest Pharmaceuticals National Institute of Allergy and Infectious Diseases and plan a phase I trial for HIV infections (Prevention) (NCT03082690)
  • 16 Jul 2014 The US FDA approves IND application for IQP 0528 in HIV infections (prevention)
  • 11 Feb 2009 Antimicrobial and animal toxicology data from preclinical trials for HIV infections presented at the 16th Conference on Retroviruses and Opportunistic Infections (CROI-2009)
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