Drug Profile


Alternative Names: Insulin-like growth factor-1 receptor (IGF-1R) antagonist antibody (fully human) - Horizon Pharma; R 1507; RG 1507; RV 001

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Genmab; Roche
  • Developer Horizon Pharma; Roche
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Insulin-like growth factor-I receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Graves ophthalmopathy
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Graves ophthalmopathy
  • Phase I Diabetic macular oedema
  • Discontinued Advanced breast cancer; Hodgkin's disease; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Sarcoma; Solid tumours

Most Recent Events

  • 08 May 2017 River Vision Development Corp has been acquired and merged into Horizon Pharma
  • 01 Aug 2016 River Vision Development completes a phase I trial for Diabetic macular oedema in USA (NCT02103283)
  • 01 Oct 2014 Phase-I clinical trials in Diabetic macular oedema in USA (IV) (NCT02103283)
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