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Teprotumumab - Horizon Therapeutics

Drug Profile

Teprotumumab - Horizon Therapeutics

Alternative Names: HZN 001; Insulin-like-growth-factor-1-receptor-antagonist-antibody-River-Vision-Development; R 1507; RG 1507; RO-4858696; RV 001-River-Vision; Tepezza; teprotumumab-trbw

Latest Information Update: 29 Feb 2024

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At a glance

  • Originator Genmab; Roche
  • Developer Halozyme Therapeutics; Horizon Therapeutics plc; Roche
  • Class Antineoplastics; Eye disorder therapies; Immunotherapies; Monoclonal antibodies; Skin disorder therapies
  • Mechanism of Action Apoptosis stimulants; Signal transduction pathway inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Graves ophthalmopathy
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Graves ophthalmopathy
  • No development reported Diabetic macular oedema; Diffuse scleroderma
  • Discontinued Advanced breast cancer; Hodgkin's disease; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Sarcoma; Solid tumours

Most Recent Events

  • 08 Feb 2024 Horizon Pharma plans a phase III trial for Graves ophthalmopathy (SC, Injection) in February 2024 (NCT06248619)
  • 06 Feb 2024 Preregistration for Graves ophthalmopathy in Japan (IV) prior to February 2024
  • 10 Jan 2024 Phase I development is ongoing for Graves ophthalmopathy in Ireland (SC) (Horizon Therapeutics pipeline, January 2024)
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