Drug Profile


Alternative Names: A 01016; Jejetrea®; Jetrea; Microplasmin; Recombinant human microplasmin; Recombinant microplasmin; THR 409

Latest Information Update: 20 May 2017

$50 / €47 *
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At a glance

  • Originator University of Leuven
  • Developer Alcon; ThromboGenics; University of Leuven
  • Class Anti-ischaemics; Eye disorder therapies; Peptide fragments; Serine endopeptidases
  • Mechanism of Action Antiplasmin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Retinal disorders; Peripheral arterial occlusive disorders
  • New Molecular Entity Yes
  • Available For Licensing Yes - Thrombosis

Highest Development Phases

  • Marketed Retinal disorders
  • Phase II Diabetic retinopathy
  • Preclinical Retinal vein occlusion
  • Suspended Deep vein thrombosis; Peripheral arterial occlusive disorders; Stroke
  • Discontinued Age-related macular degeneration; Diabetic macular oedema

Most Recent Events

  • 08 Jun 2016 Office of Biotechnology Products of the US FDA approves already diluted formulation of ocriplasmin for treatment of Retinal disorders in USA
  • 08 Jun 2016 ThromboGenics intends to launch already diluted formulation of ocriplasmin in first half of 2017 in USA
  • 01 May 2016 ThromboGenics completes the phase IV ORBIT trial in Retinal disorders (Vitreomacular adhesion/vitreomacular traction) in USA (NCT02079883)
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