Ocriplasmin

Drug Profile

Ocriplasmin

Alternative Names: A-01016; Jejetrea®; Jetrea; Microplasmin; Recombinant human microplasmin; Recombinant microplasmin; THR-409

Latest Information Update: 11 Dec 2017

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At a glance

  • Originator University of Leuven
  • Developer Alcon; ThromboGenics; University of Leuven
  • Class Anti-ischaemics; Eye disorder therapies; Peptide fragments; Serine endopeptidases
  • Mechanism of Action Antiplasmin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Retinal disorders; Peripheral arterial occlusive disorders
  • New Molecular Entity Yes
  • Available For Licensing Yes - Thrombosis

Highest Development Phases

  • Marketed Retinal disorders
  • Phase II Diabetic retinopathy
  • Preclinical Retinal vein occlusion
  • Suspended Deep vein thrombosis; Peripheral arterial occlusive disorders; Stroke
  • Discontinued Age-related macular degeneration; Diabetic macular oedema

Most Recent Events

  • 08 Dec 2017 ThromboGenics discontinues enrolment in the phase II CIRCLE trial for Diabetic Retinopathy (Non-proliferative) due to slow recruitment of patients
  • 28 Sep 2017 ThromboGenics launches 'already-diluted' formulation of Ocriplasmin for the treatment of retinal disorders, in USA
  • 18 Sep 2017 ThromboGenics to regain global rights of ocriplasmin from Alcon
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