Drug Profile


Alternative Names: Anti-CD33 MAb; HuM 195; SGN-33

Latest Information Update: 15 Sep 2010

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At a glance

  • Originator PDL BioPharma
  • Developer Seattle Genetics
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD33 antigen inhibitors; Cytokine inhibitors; Immunostimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Acute myeloid leukaemia; Myelodysplastic syndromes

Most Recent Events

  • 13 Sep 2010 Discontinued - Phase-I for Myelodysplastic syndromes in USA (IV)
  • 13 Sep 2010 Discontinued - Phase-II for Acute myeloid leukaemia in USA (IV)
  • 09 Jun 2009 Efficacy and safety data from a phase I trial in acute myeloid leukaemia and myeloproliferative diseases presented at the 14th Congress of the European Hematology Association
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