Enzastaurin

Drug Profile

Enzastaurin

Alternative Names: DB 102; Enzastaurin hydrochloride; LY-317615

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Eli Lilly
  • Developer Denovo Biopharma; Eli Lilly
  • Class Antineoplastics; Indoles; Piperidines; Pyridines; Pyrrolidinones; Small molecules
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; Protein kinase C beta inhibitors; Protein-serine-threonine kinase inhibitors; Proto oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Diffuse large B cell lymphoma; Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Clinical Phase Unknown Diffuse large B cell lymphoma
  • Discontinued Brain cancer; Breast cancer; Cancer; Colorectal cancer; Follicular lymphoma; Glioblastoma; Lung cancer; Lymphoma; Multiple myeloma; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Ovarian cancer; Prostate cancer; Renal cancer; Solid tumours; Waldenstrom's macroglobulinaemia

Most Recent Events

  • 17 Feb 2017 Clinical trials in Diffuse large B cell lymphoma (First-line therapy) in USA and China (PO)
  • 16 Feb 2017 Denovo Biopharma plans a randomised, double-blind, placebo-controlled, global phase III trial for Diffuse large B cell lymphoma (DGM1 biomarker positive, First-line therapy) in USA and China (PO)
  • 16 Feb 2017 Denovo Biopharma files an IND application with the Chinese FDA for Diffuse large B cell lymphoma (First-line therapy)
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