Drug Profile


Alternative Names: AP 2/09-DS; AP-12009; AP-2/09; OT-101; OT-201; Personalised dosing TGF-beta antisense; TGF-beta antisense

Latest Information Update: 19 Apr 2017

Price : $50

At a glance

  • Originator Antisense Pharma
  • Developer Autotelic; Oncotelic
  • Class Antineoplastics; Oligodeoxyribonucleotides; Thionucleotides
  • Mechanism of Action Transforming growth factor beta2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer; Glioma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Glioblastoma
  • Phase II/III Malignant melanoma; Pancreatic cancer
  • No development reported Colorectal cancer
  • Discontinued Anaplastic astrocytoma

Most Recent Events

  • 01 Apr 2017 Pharmacokinetics data from a phase I/II trial in Malignant melanoma, Pancreatic cancer and Colorectal cancer presented at the 108th Annual Meeting of the American Association for Cancer Research (AACR-2017)
  • 07 Sep 2016 Trabedersen is still in phase II/III trials for Glioblastoma in Georgia and Israel (Oncotelic pipeline, September 2016)
  • 07 Sep 2016 Trabedersen is still in phase II/III trials for Malignant melanoma in Germany (Oncotelic pipeline, September 2016)
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