Drug Profile


Alternative Names: BMN-165; PEG-PAL; PEGylated recombinant phenylalanine ammonia lyase; Phenylase; rAvPAL-PEG; Recombinant Anabaena variabilis phenylalanine ammonia lyase

Latest Information Update: 04 Jul 2017

$50 / €47 *
* $ price applies to USA, Canada and Latin America. € price applies to the rest of the world. Final gross prices may vary according to local VAT.

At a glance

  • Originator IBEX Technologies
  • Developer BioMarin Pharmaceutical
  • Class Ammonia lyases; Enzymes; Recombinant proteins
  • Mechanism of Action Phenylalanine ammonia lyase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Phenylketonuria
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Phenylketonuria

Most Recent Events

  • 30 Jun 2017 Preregistration for Phenylketonuria in USA (SC)
  • 30 Jun 2017 BioMarin Pharmaceutical announces intention to submit MAA in the EU for Phenylketonuria, by the end of 2017
  • 04 May 2017 BioMarin announces intention to submit BLA to US FDA for Phenylketonuria in the second quarter of 2017
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