Combretastatin A1 phosphate

Drug Profile

Combretastatin A1 phosphate

Alternative Names: CA1; CA1P; Combrestatin A1 diphosphate; Combretastatin A1 di-phosphate; OXi 4503

Latest Information Update: 02 Aug 2017

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At a glance

  • Originator Arizona State University
  • Developer Mateon Therapeutics
  • Class Antineoplastics; Combretastatins; Diphosphates; Stilbenes
  • Mechanism of Action Tubulin polymerisation inhibitors; Vascular disrupting agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity No
  • Available For Licensing Yes - Acute myeloid leukaemia

Highest Development Phases

  • Phase I/II Acute myeloid leukaemia; Liver cancer; Liver metastases; Myelodysplastic syndromes
  • Phase I Solid tumours

Most Recent Events

  • 01 Aug 2017 Additional safety and efficacy data from a phase Ib trial in Acute myeloid leukaemia released by Mateon Therapeutics
  • 12 Jun 2017 Efficacy data from a phase I/II trial in Acute myeloid leukaemia released by Mateon Therapeutics
  • 07 Jun 2017 Combretastatin A1 phosphate receives Fast Track designation for Acute myeloid leukaemia [IV,Infusion] in USA
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