Albumin-bound paclitaxel - Abraxis BioScience

Drug Profile

Albumin-bound paclitaxel - Abraxis BioScience

Alternative Names: ABI-007; Abraxane; Coraxane; Coroxane; Nab-Paclitaxel; Systemic nanoparticle albumin-bound paclitaxel

Latest Information Update: 16 Oct 2017

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At a glance

  • Originator Abraxis BioScience
  • Developer Abraxis BioScience; Australian and New Zealand Urogenital and Prostate Cancer Group; Big Ten Cancer Research Consortium; Cambridge University Hospitals; Cancer Research UK; Celgene Corporation; Columbia University; Eli Lilly; Genentech; M. D. Anderson Cancer Center; Mayo Clinic; NCIC Clinical Trials Group; New York University School of Medicine; Oncosur; PrECOG; Southeastern Gynecologic Oncology; Taiho Pharmaceutical; University of California, Davis; University of Iowa; University of Texas M. D. Anderson Cancer Center; Washington University School of Medicine
  • Class Antineoplastics; Diterpenes; Paclitaxels; Small molecules; Taxanes
  • Mechanism of Action Angiogenesis inhibitors; Mitosis inhibitors; Platelet-derived growth factor inhibitors; Proto-oncogene protein c-bcl-2 inhibitors; Tubulin inhibitors; Tubulin polymerisation promoters
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma; Pancreatic cancer
  • New Molecular Entity No

Highest Development Phases

  • Marketed Breast cancer; Gastric cancer; Non-small cell lung cancer; Pancreatic cancer
  • Phase II Biliary cancer; Cholangiocarcinoma; Colorectal cancer; Head and neck cancer; Malignant melanoma; Small cell lung cancer; Urogenital cancer
  • Phase I/II Multiple myeloma; Solid tumours
  • No development reported Bladder cancer; Ovarian cancer; Prostate cancer
  • Discontinued Coronary artery restenosis; Peripheral arterial disorders; Vascular restenosis

Most Recent Events

  • 21 Sep 2017 Phase-II clinical trials in Gastric cancer (Late-stage disease, Metastatic disease, Inoperable/Unresectable, Combination therapy, First-line therapy) in USA (IV) (NCT03283761)
  • 08 Sep 2017 Updated efficacy and adverse events data from the phase III ABOUND.sqm trial in Non-small cell lung cancer presented at the 42nd European Society for Medical Oncology Congress
  • 08 Sep 2017 Interim efficacy and adverse events data from the phase II LAPACT trial in Pancreatic cancer presented at the 42nd European Society for Medical Oncology Congress (ESMO-2017)
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