Drug Profile


Alternative Names: Clm-001; R-667; RG-667; RO-3300074

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Roche
  • Developer Clementia Pharmaceuticals; Roche
  • Class Benzoic acids; Naphthalenes; Pyrazoles; Small molecules
  • Mechanism of Action Retinoic acid receptor gamma agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Fibrodysplasia ossificans progressiva
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Fibrodysplasia ossificans progressiva
  • Discontinued Emphysema

Most Recent Events

  • 28 Mar 2017 Updated interim adverse events and efficacy data from a phase II open label extension study in Fibrodysplasia ossificans progressiva released by Clementia Pharmaceuticals
  • 14 Nov 2016 Clementia Pharmaceuticals suspends enrolment in a phase II trial for Fibrodysplasia ossificans progressiva in USA (NCT02521792)
  • 01 Nov 2016 Clementia Pharmaceuticals initiates an extension phase II trial for Fibrodysplasia ossificans progressiva (In adolescents, In adults, In children) in France (PO) (NCT02979769)
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