Drug Profile


Alternative Names: ACT-108475; AXV 034; AXV 034343; Pivlaz

Latest Information Update: 19 Sep 2017

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At a glance

  • Originator Chugai Pharmaceutical; Roche
  • Developer Idorsia Pharmaceuticals
  • Class Anti-ischaemics; Dioxanes; Neuroprotectants; Pyridines; Pyrimidines; Small molecules; Sulfonamides; Tetrazoles
  • Mechanism of Action Endothelin A receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cerebral vasospasm
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Cerebral vasospasm

Most Recent Events

  • 03 Aug 2017 Actelion Pharmaceuticals completes a phase II trial for Cerebral vasospasm in Japan and South Korea (IV, Infusion) (JapicCTI-152889)
  • 16 Jun 2017 Actelion Pharmaceuticals has been acquired by Janssen Pharmaceuticals
  • 16 Jun 2017 Actelion Pharmaceuticals spun off its drug discovery operations and early-stage clinical development assets into a newly created company, Idorsia
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