Axitinib

Drug Profile

Axitinib

Alternative Names: AG-013736; AG-13,736; Inlyta

Latest Information Update: 10 Oct 2017

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At a glance

  • Originator Pfizer
  • Developer Grupo Espanol de Tumores Neuroendocrinos; H. Lee Moffitt Cancer Center and Research Institute; Merck Sharp & Dohme; Netherlands Cancer Institute; Pfizer; SCRI Development Innovations; SFJ Pharmaceuticals; University of Cincinnati; University of Texas M. D. Anderson Cancer Center; University of Wisconsin-Madison
  • Class Antineoplastics; Eye disorder therapies; Imidazoles; Indazoles; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; Platelet-derived growth factor beta receptor antagonists; Proto oncogene protein c-kit inhibitors; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Renal cell carcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Renal cell carcinoma
  • Phase II/III Neuroendocrine tumours
  • Phase II Carcinoid tumour; Colorectal cancer; Glioblastoma; Non-small cell lung cancer; Prostate cancer
  • Phase I Hepatocellular carcinoma; Solid tumours
  • Discontinued Breast cancer; Gastric cancer; Gastrointestinal cancer; Liver cancer; Pancreatic cancer; Thyroid cancer

Most Recent Events

  • 08 Sep 2017 Phase-I clinical trials in Hepatocellular carcinoma (Late-stage disease, Combination therapy, First-line therapy) in Japan (PO) (NCT03289533)
  • 18 Aug 2017 Pfizer terminates a phase II trial in Glioblastoma (Newly diagnosed, In the elderly) due to transfer of study sponsor in USA (PO) (NCT01508117)
  • 02 Jun 2017 Updated efficacy and adverse events data from a phase Ib trial in Renal cell carcinoma presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
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