Axitinib

Drug Profile

Axitinib

Alternative Names: AG-013736; AG-13,736; Inlyta

Latest Information Update: 15 Feb 2017

Price : $50

At a glance

  • Originator Pfizer
  • Developer H. Lee Moffitt Cancer Center and Research Institute; Merck Sharp & Dohme; Netherlands Cancer Institute; Pfizer; SCRI Development Innovations; SFJ Pharmaceuticals; University of Texas M. D. Anderson Cancer Center; University of Wisconsin-Madison
  • Class Antineoplastics; Imidazoles; Indazoles; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; Platelet-derived growth factor beta receptor antagonists; Proto oncogene protein c-kit inhibitors; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Renal cell carcinoma
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Renal cell carcinoma
  • Phase II Carcinoid tumour; Colorectal cancer; Glioblastoma; Non-small cell lung cancer; Prostate cancer
  • Phase I Solid tumours
  • Discontinued Breast cancer; Gastric cancer; Gastrointestinal cancer; Liver cancer; Pancreatic cancer; Thyroid cancer

Most Recent Events

  • 09 Oct 2016 Phase-III clinical trials in Renal cell carcinoma (Combination therapy, First-line therapy, Late-stage disease) (PO)
  • 09 Oct 2016 Efficacy data from a phase Ib trial in Renal cell carcinoma (Late-stage disease, Combination therapy, Treatment-naive) and the phase Ib JAVELIN Renal 100 trial in Renal cell carcinoma (Late-stage disease, Combination therapy) released by Pfizer
  • 09 Oct 2016 Pfizer initiates enrolment in a phase III trial for Renal cell carcinoma (Combination therapy, First-line therapy, Late-stage disease) (PO)
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