Sunitinib

Drug Profile

Sunitinib

Alternative Names: PHA-290940; PHA-290940AD; PNU-290940; PNU-290940AD; SU-011248; SU-11248; SU-11428; Sunitinib malate; Sutent

Latest Information Update: 04 Nov 2017

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At a glance

  • Originator Pfizer
  • Developer Australasian Sarcoma Study Group; Cancer Research UK; Case Comprehensive Cancer Center; Clatterbridge Cancer Centre NHS Foundation Trust; Hoosier Cancer Research Network; Korean Urological Oncology Society; Memorial Sloan-Kettering Cancer Center; Ohio State University; Pfizer; University of Michigan Comprehensive Cancer Center; University of Texas M. D. Anderson Cancer Center; US Oncology Research
  • Class Amides; Antineoplastics; Ethylamines; Fluorobenzenes; Indoles; Pyrroles; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; Colony stimulating factor receptor antagonists; Fms-like tyrosine kinase 3 inhibitors; Platelet derived growth factor alpha receptor antagonists; Platelet-derived growth factor beta receptor antagonists; Proto oncogene protein c ret inhibitors; Proto oncogene protein c-kit inhibitors; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastrointestinal stromal tumours; Renal cell carcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Gastrointestinal stromal tumours; Pancreatic cancer; Renal cell carcinoma
  • Phase II Bladder cancer; Malignant melanoma; Oesophageal cancer; Pheochromocytoma; Prostate cancer; Thyroid cancer
  • Phase I/II Soft tissue sarcoma
  • No development reported Germ cell and embryonal neoplasms; Hepatocellular carcinoma
  • Discontinued Breast cancer; Colorectal cancer; Gastric cancer; Non-small cell lung cancer; Urogenital cancer

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for phase-I development in Prostate-cancer(Combination therapy) in USA (PO, Capsule)
  • 13 Oct 2017 Adverse events data from the phase III S-TRAC trial in Renal cell carcinoma presented at the 42nd European Society for Medical Oncology Congress (ESMO-2017)
  • 19 Sep 2017 The US FDA's Oncologic Drug Advisory Committee adopts a positive opinion for the use of sunitinib (Adjuvant therapy, First line therapy) for Renal cell carcinoma
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