Oportuzumab monatox

Drug Profile

Oportuzumab monatox

Alternative Names: Anti-ECAM exotoxin A fusion protein; Proxinium; VB-4847; VB-845; VB4-845; Vicinium

Latest Information Update: 22 Jun 2017

Price : $50

At a glance

  • Originator University of Zurich
  • Developer Eleven Biotherapeutics; Viventia Biotechnologies
  • Class Antineoplastics; Drug conjugates; Immunotoxins; Monoclonal antibodies; Recombinant fusion proteins
  • Mechanism of Action Protein synthesis inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Head and neck cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Bladder cancer
  • Phase II/III Head and neck cancer
  • No development reported Liver cancer; Ovarian cancer

Most Recent Events

  • 07 Jun 2017 Eleven therapeutics, National Cancer Institute (NCI) and AstraZeneca agree to co-develop ViciniumTM in combination with durvalumab for the treatment of non-muscle invasive bladder cancer
  • 07 Jun 2017 Eleven Biotherapeutics plans a phase I trial for the treatment of non-muscle invasive bladder cancer
  • 03 Apr 2017 Pharmacodynamics data from preclinical studies in Cancer released by Eleven Biotherapeutics
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