AP 5346

Drug Profile

AP 5346

Alternative Names: AP5346; ASK-H03; Polymer-DACH platinum conjugate - PlasmaTech Biopharmaceuticals; ProLindac

Latest Information Update: 05 Aug 2015

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At a glance

  • Originator University of London School of Pharmacy
  • Developer PlasmaTech Biopharmaceuticals
  • Class Antineoplastics; Platinum complexes
  • Mechanism of Action Alkylating agents; DNA cross linking agents; DNA synthesis inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Cholangiocarcinoma; Colorectal cancer; Head and neck cancer; Ovarian cancer

Most Recent Events

  • 31 Dec 2011 Phase-II clinical trials in Cholangiocarcinoma in Europe (IV)
  • 01 Nov 2010 Phase-II clinical trials in Ovarian cancer (Combination therapy, Second-line therapy or greater, Late-stage disease, Metastatic disease) in France (IV) (EudraCT2010-020030-25)
  • 21 Apr 2009 Pharmacokinetics data from a Preclinical trial presented at the 100th Annual Meeting of the American Association for Cancer Research (AACR-2009)
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