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Drug Profile

Sprifermin - Merck

Alternative Names: AS-902330; FGF-18; rhFGF-18; Zfgf5

Latest Information Update: 01 Jan 2024

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At a glance

  • Originator ZymoGenetics
  • Developer Merck Serono; Molecular Therapeutics; Nordic Bioscience; Pfizer
  • Class Fibroblast growth factors; Neuroprotectants
  • Mechanism of Action Fibroblast growth factor stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Osteoarthritis
  • Discontinued Cartilage disorders; Stroke

Most Recent Events

  • 10 Nov 2023 Efficacy data from the FORWARD phase II trial in Osteoarthritis presented at the ACR Convergence 2023
  • 10 Jan 2022 Sprifermin licensed to Trialspark worldwide
  • 15 Apr 2021 Sprifermin is still in phase II FORWARD trial for Osteoarthritis in Argentina, Czech Republic, Estonia, Denmark, Hong Kong, Poland, Romania and USA (Intra-articular) (NCT01919164)

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