PX 478

Drug Profile

PX 478

Alternative Names: PX-478

Latest Information Update: 21 Apr 2011

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At a glance

  • Originator ProlX Pharmaceuticals
  • Developer Oncothyreon
  • Class Antineoplastics; Mustard compounds; Phenylpropionates; Small molecules
  • Mechanism of Action Hypoxia-inducible factor-1 alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Discontinued Lymphoma; Solid tumours

Most Recent Events

  • 08 Jun 2010 Efficacy, adverse events, pharmacodynamics and pharmacokinetics data from a Phase-I trial in Cancer presented at the 46th Annual Meeting of the American Society of Clinical Oncology (ASCO-2010) ,
  • 14 May 2010 Oncothyreon completes a phase I trial in Solid tumours and lymphoma in USA
  • 16 Apr 2008 Pharmacodynamics data from a preclinical trial in Cancer presented at the 99th Annual Meeting of the American Association for Cancer Research (AACR-2008) ,,
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