Belinostat

Drug Profile

Belinostat

Alternative Names: Beleodaq; CLN-9; ComboBelCHOP; PDX 101; PX-105684; PXD 101

Latest Information Update: 28 Dec 2016

Price : $50

At a glance

  • Originator TopoTarget
  • Developer CIMA- Universidad de Navarra; Emory University; National Cancer Institute (USA); Onxeo SA; Spectrum Pharmaceuticals; TopoTarget
  • Class Acrylamides; Antineoplastics; Hydroxamic acids; Small molecules; Sulfonamides
  • Mechanism of Action Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Peripheral T-cell lymphoma; Thymoma
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    Peripheral T-cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Peripheral T-cell lymphoma
  • Phase II B cell lymphoma; Glioblastoma
  • Phase I/II Non-small cell lung cancer
  • Phase I Acute myeloid leukaemia; Lymphoma; Myelodysplastic syndromes; Small cell lung cancer; Solid tumours
  • Preclinical Hepatocellular carcinoma
  • No development reported Bladder cancer; Carcinoma; Colorectal cancer; Cutaneous T cell lymphoma; Fallopian tube cancer; Mesothelioma; Ovarian cancer; Peritoneal cancer; Soft tissue sarcoma; Thymoma
  • Discontinued Multiple myeloma

Most Recent Events

  • 14 Nov 2016 The National Cancer Institute terminates a phase-I/II clinical trial in Thymoma (first-line therapy, combination therapy) in USA (IV) (NCT01100944)
  • 27 Oct 2016 Onxeo plans a phase III trial for Peripheral T-cell lymphoma (Combination therapy, First line therapy) in Europe and USA (IV)
  • 27 Oct 2016 Pharmacodynamics data from preclinical studies in Hepatocellular carcinoma released by Onxeo SA
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