Drug Profile


Alternative Names: BMS-982470; IL-21; Interleukin 21 - ZymoGenetics; rIL-21

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator ZymoGenetics
  • Developer National Cancer Institute (Canada); ZymoGenetics
  • Class Antineoplastics; Interleukins
  • Mechanism of Action Immunostimulants; Natural killer cell stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma
  • New Molecular Entity No

Highest Development Phases

  • No development reported Malignant melanoma; Non-Hodgkin's lymphoma; Renal cancer; Solid tumours
  • Discontinued Viral infections

Most Recent Events

  • 01 Dec 2014 Bristol-Myers Squibb completes a phase I trial for Solid tumours in USA (NCT01629758)
  • 01 Jun 2014 Bristol-Myers Squibb completes a phase I trial in Malignant melanoma (Combination therapy, Late stage disease) in USA and Puerto Rico (NCT01489059)
  • 01 Jul 2012 Phase-I clinical trials in Solid tumours (late-stage disease, combination therapy) in USA (IV)
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