Drug Profile


Alternative Names: pasireotide-LAR; Signifor; Signifor LAR; SOM-230; SOM-230-LAR; SOM230C

Latest Information Update: 12 Jun 2017

Price : $50

At a glance

  • Originator Novartis
  • Developer H. Lee Moffitt Cancer Center and Research Institute; Novartis; UNC Lineberger Comprehensive Cancer Center; University of Arkansas for Medical Sciences; University of Miami
  • Class Antineoplastics; Cyclic peptides; Macrocyclic compounds; Oligopeptides; Peptidomimetics
  • Mechanism of Action Corticotropin-releasing factor antagonists; Growth hormone releasing factor antagonists; Insulin-like growth factor I inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acromegaly; Pituitary ACTH hypersecretion; Neuroendocrine tumours
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Pituitary ACTH hypersecretion
  • Registered Acromegaly
  • Phase III Pancreatic disorders
  • Phase II Cluster headache; Gastrointestinal disorders; Gigantism; Hepatocellular carcinoma; Meningioma; Neuroendocrine tumours; Pituitary cancer; Prostate cancer; Uveal melanoma
  • Phase I Gastrointestinal cancer; Malignant melanoma; Merkel cell carcinoma; Pancreatic cancer
  • Preclinical Radiation injuries
  • Discontinued Carcinoid tumour

Most Recent Events

  • 10 Apr 2017 Novartis completes a phase II trial for Acromegaly and Gigantism in Japan (IM) (NCT01673646)
  • 10 Apr 2017 Novartis completes a phase III trial for Pituitary ACTH Hypersecretion in USA, Argentina, Belgium, Brazil, Canada, China, France, Germany, India, Israel, Italy, Japan, Netherlands, Peru, Poland, Russia, Spain, Thailand, Turkey and United Kingdom (NCT01374906)
  • 05 Apr 2017 Safety data from the phase II CAPACITY trial in Pituitary ACTH Hypersecretion presented at the The 99th Annual Meeting of the Endocrine Society (ENDO-2017)
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