Drug Profile


Alternative Names: Arestvyr; SIGA-246; ST-246®; TPOXX

Latest Information Update: 25 Apr 2017

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At a glance

  • Originator ViroPharma
  • Developer Biomedical Advanced Research and Development Authority; SIGA Technologies
  • Class Antivirals; Benzamides; Indoles; Small molecules
  • Mechanism of Action Viral envelope protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Smallpox; Orthopoxvirus infections
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Orthopoxvirus infections
  • Preclinical Smallpox

Most Recent Events

  • 21 Apr 2017 SIGA Technologies completes enrolment in its phase I trial for Orthopoxvirus infections in USA (IV)
  • 17 Jan 2017 SIGA Technologies has patent protection for methods of preparing tecovirimat in USA (SIGA Technologies Form 10-K, March 2017)
  • 29 Aug 2016 Adverse events data from a phase III trial in Orthopoxvirus infections released by SIGA Therapeutics
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