Drug Profile


Alternative Names: Anti-α5β1 integrin antibody; Eos 200-4; M 200

Latest Information Update: 15 Dec 2016

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At a glance

  • Originator PDL BioPharma
  • Developer Abbott Biotherapeutics Corp; Biogen Idec; National Cancer Institute (USA); OphthoTech Corporation; PDL BioPharma
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Angiogenesis inhibitors; Integrin alpha 5 beta 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Age-related macular degeneration
  • No development reported Intestinal cancer; Non-small cell lung cancer; Peritoneal cancer
  • Discontinued Malignant melanoma; Pancreatic cancer; Renal cell carcinoma

Most Recent Events

  • 24 Jan 2013 Discontinued - Phase-II for Ovarian cancer (monotherapy, second-line) in USA (IV)
  • 24 Jan 2013 Discontinued - Phase-II for Ovarian cancer (monotherapy, second-line) in Canada (IV)
  • 24 Jan 2013 Discontinued - Phase-II for Peritoneal cancer (monotherapy, second-line) in Canada (IV)
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