Mipomersen

Drug Profile

Mipomersen

Alternative Names: ISIS-301012; Kynamro; Mipomersen sodium

Latest Information Update: 25 Mar 2017

Price : $50

At a glance

  • Originator Isis Pharmaceuticals
  • Developer Genzyme Corporation; Ionis Pharmaceuticals; Isis Pharmaceuticals
  • Class Antihyperlipidaemics; Antisense oligonucleotides; Oligodeoxyribonucleotides
  • Mechanism of Action Apolipoprotein B inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hyperlipoproteinaemia type IIa
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Hyperlipoproteinaemia type IIa
  • Phase III Hypercholesterolaemia
  • No development reported Atherosclerosis

Most Recent Events

  • 03 May 2016 Kastle Therapeutics acquires Mipomersen from Ionis Pharmaceuticals
  • 01 Feb 2016 Genzyme completes a phase III trial in severe heterozygous familial Hypercholesterolaemia (Adjunctive treatment) in USA, Canada, Israel, South Africa, Argentina, Australia, Belgium, Brazil, Croatia, Czech Republic, Denmark, Germany, Greece, Hong Kong, Hungary, India, Italy, South Korea, Malaysia, Netherlands, New Zealand, Norway, Poland, Russia, Spain, Sweden, Taiwan, Turkey, Ukraine and United Kingdom (SC) (NCT01475825)
  • 11 Jan 2016 Ionis Pharmaceuticals terminates Genzyme's licence for mipomersen worldwide
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