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Drug Profile

Otelixizumab

Alternative Names: ChAglyCD3; GSK-2136525; Humanised anti-CD3 monoclonal antibody - Tolerx; TRX4

Latest Information Update: 13 Sep 2024

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At a glance

  • Originator BTG
  • Developer GlaxoSmithKline; GSK; Tolerx
  • Class Antihyperglycaemics; Antipsoriatics; Antirheumatics; Eye disorder therapies; Monoclonal antibodies
  • Mechanism of Action Immunosuppressants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Type 1 diabetes mellitus
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Type 1 diabetes mellitus
  • Discontinued Graves ophthalmopathy; Multiple sclerosis; Myasthenia gravis; Psoriasis; Psoriatic arthritis; Rheumatoid arthritis

Most Recent Events

  • 19 Aug 2019 BTG has been acquired by Boston Scientific Corporation
  • 27 Sep 2018 GlaxoSmithKline completes a phase II trial in Type-1 diabetes mellitus in Belgium (IV) (NCT02000817)
  • 11 Oct 2017 GlaxoSmithKline terminates the phase I TTEDD trial in Type-1 diabetes mellitus in USA and Canada (IV) (NCT00451321)

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