Drug Profile


Alternative Names: Anti-CXCL10 antibody; Anti-IP10 antibody; BMS-936557; MDX-1100

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Medarex
  • Developer Bristol-Myers Squibb; Medarex
  • Class Antirheumatics; Antiulcers; Monoclonal antibodies
  • Mechanism of Action Chemokine CXCL10 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Crohn's disease; Ulcerative colitis
  • Discontinued Multiple sclerosis; Rheumatoid arthritis; Spinal cord injuries

Most Recent Events

  • 04 Oct 2015 No recent reports of development identified - Phase-II for Ulcerative colitis in Russia, Ukraine, Poland, Romania, Mexico, Latvia, Mexico, Czech Republic, France, Netherlands, Hungary, Germany, Italy, Belgium, South Africa, Canada, Australia, Brazil, Austria, USA (IV)
  • 04 Oct 2015 No recent reports of development identified - Phase-II for Crohn's disease (Treatment-experienced) in Poland, Israel, France, Belgium, Hungary, USA, Puerto Rico and South Africa (IV)
  • 01 Dec 2014 Bristol-Myers Squibb completes a phase II trial in Crohn's disease in USA, Belgium, France, Hungary, Israel, Poland, Puerto Rico and South Africa (NCT01466374)
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