Sitagliptin

Drug Profile

Sitagliptin

Alternative Names: Glactiv; Januvia; MK-0431; MK-431; ONO-5435; Tesavel; Xelevia

Latest Information Update: 05 Oct 2017

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At a glance

  • Originator Merck & Co; Merck Sharp & Dohme
  • Developer Banyu; Merck & Co; Merck Sharp & Dohme; Ono Pharmaceutical; Pfizer; University of Colorado at Denver; Washington University School of Medicine
  • Class Antihyperglycaemics; Pyrazines; Small molecules; Triazoles
  • Mechanism of Action CD26 antigen inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Type 2 diabetes mellitus
  • Discontinued Type 1 diabetes mellitus

Most Recent Events

  • 11 Sep 2017 Adverse events and efficacy data from a phase III trial in Type 2 diabetes mellitus presented at the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD-2017)
  • 11 Sep 2017 Efficacy and adverse events data from a pooled analysis in Type 2 diabetes mellitus presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD 2017)
  • 07 Apr 2017 Merck receives complete response letter from the FDA for sitagliptin and it's combination treatment of patients with Type 2 diabetes mellitus
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