Drug Profile


Alternative Names: Bosulif; PF-05208763; PF-5208763; SKI-606

Latest Information Update: 07 Nov 2017

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At a glance

  • Originator Wyeth
  • Developer Avillion; Massachusetts General Hospital; Pfizer; University of Texas M. D. Anderson Cancer Center
  • Class Aniline compounds; Antineoplastics; Nitriles; Piperazines; Quinolines; Small molecules
  • Mechanism of Action Bcr-abl tyrosine kinase inhibitors; Src-Family kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Chronic myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Chronic myeloid leukaemia
  • Phase II Glioblastoma
  • Phase I/II Acute lymphoblastic leukaemia
  • Discontinued Autosomal dominant polycystic kidney disease; Breast cancer; Solid tumours

Most Recent Events

  • 29 Aug 2017 Bosutinib receives priority review status for Chronic myeloid leukaemia (First-line therapy, Newly diagnosed) in USA
  • 29 Aug 2017 EMA validated for review a Type II Variation application for bosutinib for Chronic myeloid leukaemia (First-line therapy, Newly diagnosed)
  • 29 Aug 2017 The US FDA accepts sNDA for bosutinib for Chronic myeloid leukaemia (First-line therapy, Newly diagnosed) for review
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