Brentuximab vedotin - Seattle Genetics/Takeda

Drug Profile

Brentuximab vedotin - Seattle Genetics/Takeda

Alternative Names: Adcetris; Anti-CD30-MMAE; Anti-CD30-monoclonal-antibody-cAC10-auristatin-E-conjugate; Auristatin-E-anti-CD30-monoclonal-antibody-cAC10-conjugate; cAC10-vcMMAE; MMAE-anti-CD30; SGN-35

Latest Information Update: 14 Dec 2017

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At a glance

  • Originator Seattle Genetics; Stanford University
  • Developer Bristol-Myers Squibb; Celgene Corporation; Dana-Farber Cancer Institute; Fondazione Italiana Linfomi; Fox Chase Cancer Center; Immune Tolerance Network; Lymphoma Academic Research Organisation; Massachusetts General Hospital; National Cancer Institute (USA); National Institute of Allergy and Infectious Diseases; Seattle Genetics; Stanford University; Takeda; Takeda Oncology; UNC Lineberger Comprehensive Cancer Center
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunoconjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hodgkin's disease; Non-Hodgkin's lymphoma; Anaplastic large cell lymphoma; Peripheral T-cell lymphoma; Cutaneous T cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Anaplastic large cell lymphoma; Cutaneous T cell lymphoma; Hodgkin's disease; Mycosis fungoides
  • Phase III T cell lymphoma
  • Phase II Adult T-cell leukaemia-lymphoma; Diffuse large B cell lymphoma; Germ cell and embryonal neoplasms; Mastocytosis; Mesothelioma; Non-Hodgkin's lymphoma; Peripheral T-cell lymphoma; Sezary syndrome
  • Phase I/II Diffuse scleroderma
  • Phase I Graft-versus-host disease
  • Discontinued Leukaemia; Multiple myeloma; Solid tumours; Systemic lupus erythematosus

Most Recent Events

  • 10 Dec 2017 Long term efficacy data from a phase I trial in Anaplastic large cell lymphoma presented at the 59th American Society of Hematology Annual Meeting (ASH-2017)
  • 10 Dec 2017 Adverse event and efficacy data from the phase III ECHELON-1 trial in Hodgkin's disease released by Takeda and Seattle Genetics (9228880; 9228848)
  • 09 Dec 2017 Updated efficacy and adverse events data from the phase III ALCANZA trial in Cutaneous T-Cell lymphoma presented at the 59th American Society of Haematology Annual Meeting (ASH-2017)
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