Drug Profile


Alternative Names: Cogane; JNX-1001; PYM-50028; Smilagenin

Latest Information Update: 26 Jun 2015

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At a glance

  • Originator Phytopharm
  • Developer IXICO
  • Class Antidementias; Herbal medicines; Neuroprotectants; Nootropics; Small molecules; Steroid sapogenins
  • Mechanism of Action Brain derived neurotrophic factor agonists; Glial cell line-derived neurotrophic factor agonists; Neuron stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Amyotrophic lateral sclerosis
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Suspended Alzheimer's disease; Amyotrophic lateral sclerosis; Glaucoma; Parkinson's disease

Most Recent Events

  • 23 May 2013 Phytopharm conducts discussions with external parties for further development of sarsasapogenin under licensing arrangements
  • 28 Feb 2013 Efficacy data from the phase II CONFIDENT-PD trial in Parkinson's disease released by Phytopharm
  • 18 Apr 2012 Pharmacodynamics data from a preclinical trial in Amyotrophic lateral sclerosis released by Phytopharm
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