Drug Profile


Alternative Names: CRx-102; CRx-102 aligned release; Prednisolone/dipyridamole; Prednisolone/dipyridamole aligned release; Synavive; Synavive AR; Z-102

Latest Information Update: 01 Aug 2016

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At a glance

  • Originator CombinatoRx
  • Developer CombinatoRx; Zalicus
  • Class Anti-inflammatories; Antirheumatics; Corticosteroids; Glucocorticoids; Pregnadienetriols; Pyrimidines; Small molecules
  • Mechanism of Action Cyclic GMP phosphodiesterase inhibitors; Glucocorticoid receptor agonists; Immunosuppressants; Nucleoside transport protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Discontinued Inflammation; Osteoarthritis; Periodontal disorders; Rheumatoid arthritis

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 25 Jul 2016 EPIRUS Biopharmaceuticals files for Chapter 7 bankruptcy (Epirus Biopharmaceuticals 8-K, July 2016)
  • 15 Jul 2014 Zalicus has merged with EPIRUS Biopharmaceuticals
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