Doxorubicin liposomal - Celsion Corporation

Drug Profile

Doxorubicin liposomal - Celsion Corporation

Alternative Names: Liposome encapsulated doxorubicin; LTLD; LTSDEL; Lyso-thermosensitive liposomal doxorubicin; ThermoDox

Latest Information Update: 17 Aug 2017

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At a glance

  • Originator Celsion Corporation
  • Developer Brigham and Womens Hospital; Celsion Corporation; Focused Ultrasound Foundation; Harvard Medical School; University of Oxford
  • Class Anthracyclines; Cytostatic antibiotics; Doxorubicins; Small molecules
  • Mechanism of Action DNA intercalators; Reactive oxygen species stimulants; RNA synthesis inhibitors; Type II DNA topoisomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hepatocellular carcinoma
  • New Molecular Entity No

Highest Development Phases

  • Phase III Hepatocellular carcinoma
  • Phase II Breast cancer; Colorectal cancer; Liver metastases
  • Preclinical Bladder cancer; Brain cancer; Glioblastoma; Pancreatic cancer
  • Discontinued Prostate cancer

Most Recent Events

  • 13 Apr 2017 Preclinical trials in Bladder cancer in USA (IV)
  • 13 Apr 2017 Pharmacokinetics data from preclinical studies in Bladder cancer released by Celsion corporation
  • 01 Apr 2017 Celsion completes the phase I TARDOX trial in Liver metastases in United Kingdom (IV) (NCT02181075)
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