Aglatimagene besadenovec

Drug Profile

Aglatimagene besadenovec

Alternative Names: Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy; AdV-Tk; AdV-tk therapy - Advantagene; ADV/HSV-tk; CanAtak; Cancer gene therapy - Advantagene; Gene Mediated Cytotoxic Immunotherapy; GliAtak; HSV-vectored thymidine kinase; OncAtak; PancAtak; ProstAtak; TKR therapy - Advantagene; Virafir

Latest Information Update: 04 May 2017

Price : $50

At a glance

  • Originator Advantagene
  • Developer Advantagene; Methodist Healthcare Ministries of South Texas
  • Class Antineoplastics; Gene therapies; Gene-directed enzyme-prodrug therapies
  • Mechanism of Action Thymidine kinase expression stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Brain cancer
  • New Molecular Entity No

Highest Development Phases

  • Phase III Prostate cancer
  • Phase II Glioma; Pancreatic cancer
  • Phase I/II Malignant pleural effusion; Ovarian cancer
  • Phase I Non-small cell lung cancer
  • Preclinical Glioblastoma; Mesothelioma; Oesophageal cancer

Most Recent Events

  • 24 Apr 2017 Phase-I clinical trials in Non-small cell lung cancer (Neoadjuvant therapy) in USA (Intratumoural) (NCT03131037)
  • 22 Dec 2016 The Methodist Hospital System plans a phase II trial in Breast cancer and Non-small cell lung cancer in USA (NCT03004183)
  • 07 Sep 2016 Phase-II clinical trials in Pancreatic cancer in USA (Intratumoural) before September 2016
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