Tofacitinib

Drug Profile

Tofacitinib

Alternative Names: Cp-690-550; CP-690550; Jaquinus; Tasocitinib; Tofacitinib citrate; Xeljanz; Xeljanz XR

Latest Information Update: 27 Jun 2017

Price : $50

At a glance

  • Originator Pfizer
  • Developer Johns Hopkins University; Pfizer
  • Class 2 ring heterocyclic compounds; Amides; Nitriles; Piperidines; Pyrimidines; Pyrroles; Small molecules
  • Mechanism of Action Immunosuppressants; Janus kinase 1 inhibitors; Janus kinase 3 inhibitors; Janus kinase-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Rheumatoid arthritis
  • Preregistration Psoriatic arthritis
  • Phase III Juvenile rheumatoid arthritis; Plaque psoriasis; Ulcerative colitis
  • Phase II Atopic dermatitis
  • Phase I Dermatomyositis
  • Discontinued Ankylosing spondylitis; Asthma; Crohn's disease; Dry eyes; Irritable bowel syndrome; Renal transplant rejection

Most Recent Events

  • 16 Jun 2017 Safety and efficacy results from the IIIb/IV ORAL Strategy trial in Rheumatoid arthritis released by Pfizer
  • 10 May 2017 Planned Prescription Drug User Fee Act (PDUFA) date for Psoriatic arthritis in USA (PO, Controlled-release) is 2017-12-01
  • 10 May 2017 Planned Prescription Drug User Fee Act (PDUFA) date for Psoriatic arthritis in USA (PO, Tablet) is 2017-12-01
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