Tofacitinib - Pfizer

Drug Profile

Tofacitinib - Pfizer

Alternative Names: Cp-690-550; CP-690550; Jaquinus; Tasocitinib; Tofacitinib citrate; Xeljanz; Xeljanz XR

Latest Information Update: 23 Oct 2017

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At a glance

  • Originator Pfizer
  • Developer Johns Hopkins University; Pfizer; University of Michigan
  • Class 2 ring heterocyclic compounds; Amides; Nitriles; Piperidines; Pyrimidines; Pyrroles; Small molecules
  • Mechanism of Action Immunosuppressants; Janus kinase 1 inhibitors; Janus kinase 3 inhibitors; Janus kinase-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Rheumatoid arthritis
  • Preregistration Psoriatic arthritis; Ulcerative colitis
  • Phase III Juvenile rheumatoid arthritis; Plaque psoriasis
  • Phase II Atopic dermatitis
  • Phase I/II Diffuse scleroderma
  • Phase I Dermatomyositis
  • Discontinued Ankylosing spondylitis; Asthma; Crohn's disease; Dry eyes; Irritable bowel syndrome; Renal transplant rejection

Most Recent Events

  • 16 Oct 2017 Preregistration for Ulcerative colitis in European Union (PO) before October 2017
  • 02 Oct 2017 Phase-I/II clinical trials in Diffuse scleroderma in USA (PO) (NCT03274076)
  • 18 Sep 2017 Pfizer plans a phase III trial for Ulcerative colitis (In children, In adults, In elderly) (NCT03281304)
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