Drug Profile


Alternative Names: CHIR-258; Dovitinib lactate; GFKI-258; Growth factor kinase inhibitor 258; TKI 258

Latest Information Update: 25 Mar 2017

Price : $50

At a glance

  • Originator Novartis
  • Developer Academic and Community Cancer Research United; Georgetown University; National Cancer Institute (USA); Novartis; University of California, Davis; University of Texas M. D. Anderson Cancer Center; University of Virginia; Yonsei University Health System
  • Class Antineoplastics; Benzimidazoles; Lactates; Piperazines; Quinolones; Small molecules
  • Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; Platelet-derived growth factor beta receptor antagonists; Proto oncogene protein c-kit inhibitors; Type 3 fibroblast growth factor receptor antagonists; Vascular endothelial growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Acute myeloid leukaemia; Adenocarcinoma; Breast cancer; Colorectal cancer; Endometrial cancer; Gastric cancer; Gastrointestinal stromal tumours; Haematological malignancies; Hepatocellular carcinoma; Malignant melanoma; Mesothelioma; Multiple myeloma; Neuroendocrine tumours; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer; Renal cancer; Solid tumours; Thyroid cancer; Urogenital cancer; Von Hippel-Lindau disease

Most Recent Events

  • 01 Nov 2016 Novartis completes a phase II/III trial in Solid tumours in USA, Denmark, Italy, Japan, Netherlands, Spain, Austria and Belgium (PO) (NCT02116803)
  • 26 May 2016 Novartis terminates a phase II trial in Breast cancer (Combination therapy, Second-line therapy or greater, Metastatic disease) in USA, Argentina, Austria, Belgium, Brazil, France, Hungary, Italy, Netherlands, Peru, Poland, Russia, South Africa, Spain and Taiwan due to low and slow enrolment (NCT01528345)
  • 25 Mar 2016 The National Cancer Centre and Novartis terminates a phase I trial in Gastric cancer and Colorectal cancer (Late-stage-disease, Combination therapy) in Singapore due to unfavourable toxicity profile (NCT02720926) before March 2016
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