Lenvatinib

Drug Profile

Lenvatinib

Alternative Names: E-7080; ER-203492-00; Kisplyx; Lenvatinib mesylate; Lenvima

Latest Information Update: 03 Feb 2017

Price : $50

At a glance

  • Originator Eisai Co Ltd
  • Developer Eisai Co Ltd; National University Hospital (Singapore); SFJ Pharmaceuticals
  • Class Amides; Antineoplastics; Chlorobenzenes; Cyclopropanes; Phenyl ethers; Quinolines; Small molecules; Urea compounds
  • Mechanism of Action Platelet-derived growth factor beta receptor antagonists; Proto oncogene protein c ret inhibitors; Proto oncogene protein c-kit inhibitors; Type 1 fibroblast growth factor receptor antagonists; Type 3 fibroblast growth factor receptor antagonists; Type 4 fibroblast growth factor receptor antagonists; Type-2 fibroblast growth factor receptor antagonists; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Thyroid cancer; Hepatocellular carcinoma; Malignant melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Renal cell carcinoma; Thyroid cancer
  • Phase III Hepatocellular carcinoma
  • Phase II Biliary cancer; Endometrial cancer; Malignant melanoma; Non-small cell lung cancer
  • Phase I/II Breast cancer; Solid tumours
  • Phase I Cancer; Lymphoma; Ovarian cancer
  • Discontinued Glioma

Most Recent Events

  • 31 Jan 2017 Phase-III clinical trials in Hepatocellular carcinoma (First-line therapy, Inoperable/Unresectable) in Israel (PO) before January 2017 (NCT01761266)
  • 26 Jan 2017 Preregistration for Thyroid cancer (Late-stage disease) in South Africa (PO) before January 2017
  • 25 Jan 2017 Topline adverse events data from a phase III trial in Hepatocellular carcinoma (First-line therapy, Inoperable/Unresectable) released by Eisai
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