NF-kappa-B decoy oligonucleotide - AnGes MG

Drug Profile

NF-kappa-B decoy oligonucleotide - AnGes MG

Alternative Names: AMG0101; AMG0102; AMG0103; AMS-001; MP 40; MP 41; MP 42; NDON; NF-kappa-B decoy oligo; NF-kappaB decoy; NF-kB decoy oligo; S-414114; SI-3104

Latest Information Update: 07 Sep 2017

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At a glance

  • Originator AnGes MG; Osaka University
  • Developer Aichi Gakuin University; AnGes MG; Hosokawa Micron Corporation; Medikit; Morishita Jintan; Nippon Zoki; Osaka University
  • Class Analgesics; Anti-inflammatories; Antipsoriatics; Antirheumatics; Oligonucleotides; Skin disorder therapies
  • Mechanism of Action Genetic transcription modulators; NF-kappa B inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Atopic dermatitis
  • Clinical Phase Unknown Vascular restenosis
  • Preclinical Inflammatory bowel diseases; Intervertebral disc degeneration; Musculoskeletal disorders; Pain; Respiratory tract disorders
  • Discontinued Periodontal disorders; Psoriasis; Spondylosis

Most Recent Events

  • 07 Sep 2017 NF-kappa-B decoy oligonucleotide is still at phase III development stage for moderate to severe facial Atopic dermatitis in Japan (Topical) (AnGes MG pipeline, July 2017)
  • 25 Apr 2017 The US FDA clears the Investigational New Drug application for discogenic lower back pain
  • 23 Mar 2017 AnGes submits Investigational New Drug application to the US FDA for discogenic lower back pain (9217232; 9217231)
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