TPI 287

Drug Profile

TPI 287

Alternative Names: ARC-100; NBT 287; TPI-287

Latest Information Update: 24 Nov 2016

Price : $50

At a glance

  • Originator Tapestry Pharmaceuticals
  • Developer Cortice Biosciences; H. Lee Moffitt Cancer Center and Research Institute; Tapestry Pharmaceuticals; University of California at San Francisco; University of Texas M. D. Anderson Cancer Center; Van Andel Research Institute
  • Class Antineoplastics; Taxanes
  • Mechanism of Action Microtubule protein modulators; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Progressive supranuclear palsy
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Glioblastoma
  • Phase I/II Malignant melanoma
  • Phase I Alzheimer's disease; Cancer; Corticobasal degeneration; Non-small cell lung cancer; Progressive supranuclear palsy
  • No development reported Medulloblastoma; Neuroblastoma
  • Discontinued Pancreatic cancer; Prostate cancer

Most Recent Events

  • 18 Nov 2016 Updated follow-up efficacy and adverse events data from the phase I/II CB-017 trial in Glioblastoma released by Cortice Biosciences
  • 07 Jul 2016 University of Texas M.D. Anderson Cancer Center and Cortice Biosciences terminate a phase I/II trial in Malignant melanoma (Combination therapy, In adolescents, In adults) in USA (NCT01067066)
  • 03 Jun 2016 Cortice Biosciences plans a phase III trial for Glioblastoma
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