Activated natural killer cells - NantKwest

Drug Profile

Activated natural killer cells - NantKwest

Alternative Names: aNK cells - NantKwest; CST-101; Neukoplast; NK-92 cells; ZRx-101

Latest Information Update: 21 Jun 2017

Price : $50

At a glance

  • Originator ZelleRx
  • Developer Johann Wolfgang Goethe-Universitat Frankfurt am Main; NantKwest; Rush University; University of Pittsburgh Medical Center; ZelleRx
  • Class Antineoplastics; Cell therapies
  • Mechanism of Action Natural killer cell receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Merkel cell carcinoma
  • New Molecular Entity No

Highest Development Phases

  • Phase II Merkel cell carcinoma
  • Phase I Acute myeloid leukaemia
  • Preclinical Hepatocellular carcinoma; Infections
  • No development reported Malignant melanoma; Renal cancer; Solid tumours
  • Discontinued Graft-versus-host disease; Leukaemia; Multiple myeloma; Sarcoma

Most Recent Events

  • 06 Jun 2017 NantKwest plans to expand the NANT Cancer Vaccine Program and initiate multiple clinical trials in Lung cancer, Breast cancer, Colon cancer, Head and neck cancer, Melanoma, Ovarian cancer, Urothelial cancer, Hodgkins and non-Hodgkins lymphoma, Sarcoma, and Merkel cell carcinoma
  • 09 May 2017 The US FDA authorises an Investigational New Drug Application for NANT Cancer Vaccine for a phase Ib/II trial enrolment for Pancreatic cancer
  • 19 Apr 2017 NantCell plans the phase Ib/II QUILT-3.039 trial for Pancreatic cancer (Combination therapy, Second-line therapy or greater) (NCT03136406)
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