Drug Profile


Alternative Names: ARRY-142886; ARRY-886; AZD 142886; AZD-6244; AZD-6244 hydrogen sulfate; AZD6244 Hyd-Sulfate; AZD6244 hydrogen sulphate; NSC-748727; Selumetinib hydrogen sulfate

Latest Information Update: 29 May 2017

Price : $50

At a glance

  • Originator Array BioPharma
  • Developer Array BioPharma; AstraZeneca; Cancer Research UK; Cincinnati Children's Hospital Medical Center; Merck & Co; National Cancer Centre (Singapore); National Cancer Institute (USA); Netherlands Cancer Institute; University Health Network; University of Cambridge; University of Liverpool
  • Class Antineoplastics; Benzimidazoles; Small molecules
  • Mechanism of Action MAP kinase kinase 1 inhibitors; MAP kinase kinase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Thyroid cancer; Uveal melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Thyroid cancer
  • Phase II Biliary cancer; Colorectal cancer; Gastrointestinal stromal tumours; Neurofibromatoses; Non-small cell lung cancer; Uveal melanoma
  • Phase I/II Astrocytoma; Glioma
  • Phase I Solid tumours
  • Preclinical Pancreatic cancer
  • Discontinued Acute myeloid leukaemia; Hepatocellular carcinoma; Malignant melanoma; Multiple myeloma

Most Recent Events

  • 25 May 2017 M.D. Anderson Cancer Center and AstraZeneca plans a phase I trial for Solid tumours (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA (NCT03162627)
  • 08 May 2017 Phase-II clinical trials in Neurofibromatosis (In children, In adolescents, In adults) in USA (PO) (NCT03095248)
  • 06 Apr 2017 Phase-II clinical trials in Gastrointestinal stromal tumours (In adolescents, In children, In adults, In the elderly, Inoperable/Unresectable, Late-stage disease, Metastatic disease) in USA (PO) (NCT03109301)
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