Drug Profile


Alternative Names: CAT-354

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Cambridge Antibody Technology
  • Developer Icahn School of Medicine at Mount Sinai; LEO Pharma; MedImmune
  • Class Antiasthmatics; Antifibrotics; Monoclonal antibodies; Skin disorder therapies
  • Mechanism of Action Interleukin 13 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Idiopathic pulmonary fibrosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Asthma; Atopic dermatitis
  • Phase II Alopecia areata
  • Discontinued Chronic obstructive pulmonary disease; Idiopathic pulmonary fibrosis; Ulcerative colitis

Most Recent Events

  • 07 Aug 2017 AstraZeneca completes a phase III trial For Asthma (In adolescents, In adults, Treatment-experienced) in USA, Germany, Hungary, Poland, Slovakia, Spain, Argentina, Belgium, Bulgaria, Colombia, Peru, Vietnam, Ukraine and Taiwan (NCT02161757)
  • 28 Jun 2017 Phase-III clinical trials in Atopic dermatitis (Monotherapy, Treatment-experienced) in Spain (SC) (EudraCT2016-004200-65)
  • 21 Jun 2017 AstraZeneca completes the phase II MESOS trial in Asthma in in Canada, Denmark, United Kingdom (NCT02449473)
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