Research programme: TNF antagonists - Xencor

Drug Profile

Research programme: TNF antagonists - Xencor

Alternative Names: TNF monoclonal antibodies - Xencor; Tumour necrosis factor antagonists - Xencor; XmAb 6755; Xtend-TNF

Latest Information Update: 26 Jul 2016

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At a glance

  • Originator Xencor
  • Class Monoclonal antibodies; Proteins; Tumour necrosis factors
  • Mechanism of Action RANK ligand inhibitors; Tumour necrosis factor alpha inhibitors; Tumour necrosis factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Autoimmune disorders; Bone disorders
  • Discontinued Inflammation

Most Recent Events

  • 11 Apr 2014 A biosuperior anti-TNF, Xtend-TNF, monoclonal antibody is still in preclinical trials for Autoimmune disorders in USA (Xencor's pipeline)
  • 23 Feb 2012 A biosuperior anti-TNF monoclonal antibody is in preclinical development for Autoimmune disorders in USA
  • 29 Nov 2006 Data presented at the 70th Annual Scientific Meeting of the American College of Rheumatology (ACR-2006) have been added to the Rheumatic Disease pharmacodynamics section
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