Dimethyl fumarate

Drug Profile

Dimethyl fumarate

Alternative Names: BG-00012; BG-12; BG-12 oral fumarate; Delayed-release dimethyl fumarate; Delayed-release DMF; FAG-201; Gastro-resistant dimethyl fumarate; Gastro-resistant DMF; Panaclar; Tecfidera

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Biogen Idec
  • Developer Biogen; Biogen Idec
  • Class Anti-inflammatories; Antipsoriatics; Cytoprotectives; Esters; Fumarates; Small molecules
  • Mechanism of Action NF E2 related factor 2 stimulants; NF-kappa B inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Multiple sclerosis
  • Phase I Pulmonary arterial hypertension
  • No development reported Rheumatoid arthritis
  • Discontinued Psoriasis

Most Recent Events

  • 28 Apr 2017 Interim safety and efficacy results from a phase III trial in Multiple sclerosis presented at the 32nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis presented at the 69th Annual Meeting of the American Academy of Neurology (AAN-2017)
  • 22 Apr 2017 Interim adverse events data from the phase III ENDORSE extension trial in relapsing-remitting Multiple sclerosis presented at the 69th Annual Meeting of the American Academy of Neurology (AAN-2017)
  • 01 Mar 2017 The US PTO rules against Forward Pharma in the interference proceeding between Forward Pharma’s pending US Patent Application No. 11/576 871 and Biogen’s US Patent No. 8 399 514
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